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Q: Could you summarize the key efficacy findings from the OrigAMI-4 trial, particularly response rates, duration of response, and progression-free survival, in this heavily pretreated population with head and neck squamous cell carcinoma?
Kevin Harrington, MD, PhD, FRCP, FRCR, FRSB: We presented data from the OrigAMI-4 phase 1b/2 study in patients with recurrent or metastatic head and neck cancer who had received prior treatment with an immune checkpoint blocker and a platinum-based chemotherapy.

We reported data on two populations: the safety population of 86 patients who received at least 1 dose of the drug and the efficacy population of 38 patients who had at least 2 tumor assessments or had stopped treatment for any reason. The efficacy data relate only to that smaller subset of patients.

In that group, we observed an overall response rate of 45%, with a further 45% showing disease stabilization. When we looked at the lesions themselves, 82% showed evidence of shrinkage—clear evidence of the drug’s efficacy. In the efficacy-evaluable population, the median duration of response was over seven months, median progression-free survival was 6.8 months, and median overall survival was not yet reached. These findings show that single-agent subcutaneous amivantamab, delivered on a 3-week schedule, is very efficacious in this disease.

Q: Given that these patients had progressed on both checkpoint inhibition and platinum-based chemotherapy, how clinically meaningful are the responses seen with amivantamab in this setting?
Harrington: This group of patients is very difficult to achieve responses in. Previously, single-agent chemotherapy or investigator’s choice therapies—such as cetuximab, another EGFR-targeted drug—typically achieve response rates in the single digits or low teens, usually between 5% and 15%.

To see a response rate as high as 45% in this group of patients is, we believe, clinically meaningful and hopefully leads to patient benefit.

Cloud-native architecture and high-density baseband processing improves operational efficiency, performance and TCO

Herndon, VA., 20 October 2025 – ST Engineering iDirect, a global leader in satellite communications, today announced the general availability of Intuition 1.1, its next-generation ground system. Built on cloud-native, multi-orbit architecture, this release introduces advanced capabilities designed to unify satellite operations, enhance adaptability and maximize efficiency.

The foundation of Intuition is its efficient, cloud-native architecture, which reduces compute resource requirements and is further enhanced by high-density processing savings with the XBB baseband solution. Together, these elements can reduce hardware requirements by up to 70%, significantly lowering the total cost of ownership (TCO). Its modular, microservices-based design enables seamless, low-risk deployments, including rapid feature upgrades with minimal operational disruption, while flexible cloud deployment options ensure scalability, efficiency and performance for any operational need.

“Our vision with Intuition is to redefine agility and intelligent operations across the satellite industry,” said Sridhar Kuppanna, CTO and SVP of Engineering at ST Engineering iDirect. “With its cutting-edge architecture, robust APIs to facilitate analytics, and seamless readiness for 5G NTN, Intuition empowers customers to stay ahead in the rapidly changing connectivity landscape. Our agile development practice, and accelerated release delivery cycles will ensure that our customers have access to new capabilities and ongoing innovation to drive growth.”

Intuition 1.1 integrates ST Engineering iDirect’s award-winning Mx-DMA® MRC return waveform technology with global bandwidth management and advanced mobility, enabling dynamic multi-orbit bandwidth pooling, automated resource allocation and a faster response to network demands. This combination dramatically enhances performance, reduces costs and optimizes resource allocation to support growing connectivity requirements. Additionally, satellite network resource orchestration APIs further empower operators with comprehensive control over ground and space assets, enabling them to fully leverage advancements in software-defined satellites.

Intuition, paired with ST Engineering iDirect’s AI-powered analytics platform, drives advanced network optimization and operational performance. Designed for the future, Intuition enables seamless adoption of emerging 3GPP standards and sets the stage for 5G NTN roaming in upcoming releases. By deploying Intuition today, satellite operators can maximize their return on investment, support high-density growth and maintain readiness for the next wave of industry innovation.

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Media contact:
Martyn Gettings Tank PR
Email: martyn.gettings@tank.co.uk